A sulfoximine-based inhibitor of human asparagine synthetase kills l-asparaginase-resistant leukemia cells

Hideyuki Ikeuchi; Yong Mo Ahn; Takuya Otokawa; Bunta Watanabe; Lamees Hegazy; Jun Hiratake; Nigel G.J. Richards

doi:10.1016/j.bmc.2012.07.047

A sulfoximine-based inhibitor of human asparagine synthetase kills l-asparaginase-resistant leukemia cells

Hideyuki Ikeuchi, Yong Mo Ahn, Takuya Otokawa, Bunta Watanabe, Lamees Hegazy, Jun Hiratake, Nigel G.J. Richards

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	5915-5927
Number of pages	13
Journal	Bioorganic and Medicinal Chemistry
Volume	20
Issue number	19
DOIs	https://doi.org/10.1016/j.bmc.2012.07.047
State	Published - Oct 1 2012
Externally published	Yes

ASJC Scopus Subject Areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Keywords

Acute lymphoblastic leukemia
Asparagine synthetase
Cell death
l-Asparagine amidohydrolase
MOLT-4 leukemia cell line
Structure-activity relationship
Sulfoximine
Transition-state analogue inhibitor

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10.1016/j.bmc.2012.07.047

Cite this

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title = "A sulfoximine-based inhibitor of human asparagine synthetase kills l-asparaginase-resistant leukemia cells",

keywords = "Acute lymphoblastic leukemia, Asparagine synthetase, Cell death, l-Asparagine amidohydrolase, MOLT-4 leukemia cell line, Structure-activity relationship, Sulfoximine, Transition-state analogue inhibitor",

author = "Hideyuki Ikeuchi and Ahn, {Yong Mo} and Takuya Otokawa and Bunta Watanabe and Lamees Hegazy and Jun Hiratake and Richards, {Nigel G.J.}",

year = "2012",

month = oct,

day = "1",

doi = "10.1016/j.bmc.2012.07.047",

language = "English",

volume = "20",

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journal = "Bioorganic and Medicinal Chemistry",

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T1 - A sulfoximine-based inhibitor of human asparagine synthetase kills l-asparaginase-resistant leukemia cells

AU - Ikeuchi, Hideyuki

AU - Ahn, Yong Mo

AU - Otokawa, Takuya

AU - Watanabe, Bunta

AU - Hegazy, Lamees

AU - Hiratake, Jun

AU - Richards, Nigel G.J.

PY - 2012/10/1

Y1 - 2012/10/1

KW - Acute lymphoblastic leukemia

KW - Asparagine synthetase

KW - Cell death

KW - l-Asparagine amidohydrolase

KW - MOLT-4 leukemia cell line

KW - Structure-activity relationship

KW - Sulfoximine

KW - Transition-state analogue inhibitor

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U2 - 10.1016/j.bmc.2012.07.047

DO - 10.1016/j.bmc.2012.07.047

M3 - Article

C2 - 22951255

AN - SCOPUS:84866398938

SN - 0968-0896

VL - 20

SP - 5915

EP - 5927

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

IS - 19

ER -

A sulfoximine-based inhibitor of human asparagine synthetase kills l-asparaginase-resistant leukemia cells

ASJC Scopus Subject Areas

Keywords

Access to Document

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