Advancing mitochondrial therapeutics: Synthesis and pharmacological evaluation of pyrazole-based inhibitors targeting the mitochondrial pyruvate carrier

Lingaiah Maram; Jessica M. Michael; Henry Politte; Vaishnavi S. Srirama; Aymen Hadji; Mohammad Habibi; Meredith O. Kelly; Rita T. Brookheart; Brian N. Finck; Lamees Hegazy; Kyle S. McCommis; Bahaa Elgendy

doi:10.1016/j.ejmech.2024.117150

Advancing mitochondrial therapeutics: Synthesis and pharmacological evaluation of pyrazole-based inhibitors targeting the mitochondrial pyruvate carrier

Lingaiah Maram, Jessica M. Michael, Henry Politte, Vaishnavi S. Srirama, Aymen Hadji, Mohammad Habibi, Meredith O. Kelly, Rita T. Brookheart, Brian N. Finck, Lamees Hegazy, Kyle S. McCommis, Bahaa Elgendy

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	117150
Journal	European Journal of Medicinal Chemistry
Volume	283
DOIs	https://doi.org/10.1016/j.ejmech.2024.117150
State	Published - Feb 5 2025

ASJC Scopus Subject Areas

Pharmacology
Drug Discovery
Organic Chemistry

Access to Document

10.1016/j.ejmech.2024.117150

Cite this

Maram, L., Michael, J. M., Politte, H., Srirama, V. S., Hadji, A., Habibi, M., Kelly, M. O., Brookheart, R. T., Finck, B. N., Hegazy, L., McCommis, K. S., & Elgendy, B. (2025). Advancing mitochondrial therapeutics: Synthesis and pharmacological evaluation of pyrazole-based inhibitors targeting the mitochondrial pyruvate carrier. European Journal of Medicinal Chemistry, 283, Article 117150. https://doi.org/10.1016/j.ejmech.2024.117150

Maram, L, Michael, JM, Politte, H, Srirama, VS, Hadji, A, Habibi, M, Kelly, MO, Brookheart, RT, Finck, BN, Hegazy, L, McCommis, KS & Elgendy, B 2025, 'Advancing mitochondrial therapeutics: Synthesis and pharmacological evaluation of pyrazole-based inhibitors targeting the mitochondrial pyruvate carrier', European Journal of Medicinal Chemistry, vol. 283, 117150. https://doi.org/10.1016/j.ejmech.2024.117150

@article{f5fb9525c71f4882853c4ce33cfd3a6c,

title = "Advancing mitochondrial therapeutics: Synthesis and pharmacological evaluation of pyrazole-based inhibitors targeting the mitochondrial pyruvate carrier",

author = "Lingaiah Maram and Michael, \{Jessica M.\} and Henry Politte and Srirama, \{Vaishnavi S.\} and Aymen Hadji and Mohammad Habibi and Kelly, \{Meredith O.\} and Brookheart, \{Rita T.\} and Finck, \{Brian N.\} and Lamees Hegazy and McCommis, \{Kyle S.\} and Bahaa Elgendy",

note = "Publisher Copyright: {\textcopyright} 2024 The Authors",

year = "2025",

month = feb,

day = "5",

doi = "10.1016/j.ejmech.2024.117150",

language = "English",

volume = "283",

journal = "European Journal of Medicinal Chemistry",

issn = "0223-5234",

}

TY - JOUR

T1 - Advancing mitochondrial therapeutics

T2 - Synthesis and pharmacological evaluation of pyrazole-based inhibitors targeting the mitochondrial pyruvate carrier

AU - Maram, Lingaiah

AU - Michael, Jessica M.

AU - Politte, Henry

AU - Srirama, Vaishnavi S.

AU - Hadji, Aymen

AU - Habibi, Mohammad

AU - Kelly, Meredith O.

AU - Brookheart, Rita T.

AU - Finck, Brian N.

AU - Hegazy, Lamees

AU - McCommis, Kyle S.

AU - Elgendy, Bahaa

PY - 2025/2/5

Y1 - 2025/2/5

UR - https://www.scopus.com/pages/publications/85212565238

UR - https://www.scopus.com/inward/citedby.url?scp=85212565238&partnerID=8YFLogxK

U2 - 10.1016/j.ejmech.2024.117150

DO - 10.1016/j.ejmech.2024.117150

M3 - Article

C2 - 39708766

AN - SCOPUS:85212565238

SN - 0223-5234

VL - 283

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

M1 - 117150

ER -

Advancing mitochondrial therapeutics: Synthesis and pharmacological evaluation of pyrazole-based inhibitors targeting the mitochondrial pyruvate carrier

ASJC Scopus Subject Areas

Access to Document

Other files and links

Cite this