Coumarinic acid-based cyclic prodrugs of opioid peptides that exhibit metabolic stability to peptidases and excellent cellular permeability

Olafur S. Gudmundsson; Giovanni M. Pauletti; Wei Wang; Daxian Shan; Huijuan Zhang; Binghe Wang; Ronald T. Borchardt

doi:10.1023/A:1018828207920

Coumarinic acid-based cyclic prodrugs of opioid peptides that exhibit metabolic stability to peptidases and excellent cellular permeability

Olafur S. Gudmundsson, Giovanni M. Pauletti, Wei Wang, Daxian Shan, Huijuan Zhang, Binghe Wang, Ronald T. Borchardt

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	7-15
Number of pages	9
Journal	Pharmaceutical Research
Volume	16
Issue number	1
DOIs	https://doi.org/10.1023/A:1018828207920
State	Published - 1999
Externally published	Yes

ASJC Scopus Subject Areas

Biotechnology
Molecular Medicine
Pharmacology
Pharmaceutical Science
Organic Chemistry
Pharmacology (medical)

Keywords

Caco-2 cells
Chemical and enzymatic stability
Esterase-sensitive prodrugs
Membrane permeability
Opioid peptides
Peptide delivery

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10.1023/A:1018828207920

Cite this

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title = "Coumarinic acid-based cyclic prodrugs of opioid peptides that exhibit metabolic stability to peptidases and excellent cellular permeability",

keywords = "Caco-2 cells, Chemical and enzymatic stability, Esterase-sensitive prodrugs, Membrane permeability, Opioid peptides, Peptide delivery",

author = "Gudmundsson, {Olafur S.} and Pauletti, {Giovanni M.} and Wei Wang and Daxian Shan and Huijuan Zhang and Binghe Wang and Borchardt, {Ronald T.}",

year = "1999",

doi = "10.1023/A:1018828207920",

language = "English",

volume = "16",

pages = "7--15",

journal = "Pharmaceutical Research",

issn = "0724-8741",

number = "1",

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TY - JOUR

T1 - Coumarinic acid-based cyclic prodrugs of opioid peptides that exhibit metabolic stability to peptidases and excellent cellular permeability

AU - Gudmundsson, Olafur S.

AU - Pauletti, Giovanni M.

AU - Wang, Wei

AU - Shan, Daxian

AU - Zhang, Huijuan

AU - Wang, Binghe

AU - Borchardt, Ronald T.

PY - 1999

Y1 - 1999

KW - Caco-2 cells

KW - Chemical and enzymatic stability

KW - Esterase-sensitive prodrugs

KW - Membrane permeability

KW - Opioid peptides

KW - Peptide delivery

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UR - http://www.scopus.com/inward/citedby.url?scp=0032937786&partnerID=8YFLogxK

U2 - 10.1023/A:1018828207920

DO - 10.1023/A:1018828207920

M3 - Article

C2 - 9950272

AN - SCOPUS:0032937786

SN - 0724-8741

VL - 16

SP - 7

EP - 15

JO - Pharmaceutical Research

JF - Pharmaceutical Research

IS - 1

ER -

Coumarinic acid-based cyclic prodrugs of opioid peptides that exhibit metabolic stability to peptidases and excellent cellular permeability

ASJC Scopus Subject Areas

Keywords

Access to Document

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