Coumarinic acid-based cyclic prodrugs of opioid peptides that exhibit metabolic stability to peptidases and excellent cellular permeability

Olafur S. Gudmundsson; Giovanni M. Pauletti; Wei Wang; Daxian Shan; Huijuan Zhang; Binghe Wang; Ronald T. Borchardt

doi:10.1023/A:1018828207920

Coumarinic acid-based cyclic prodrugs of opioid peptides that exhibit metabolic stability to peptidases and excellent cellular permeability

Olafur S. Gudmundsson
, Giovanni M. Pauletti
, Wei Wang
, Daxian Shan
, Huijuan Zhang
, Binghe Wang
, Ronald T. Borchardt

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	7-15
Number of pages	9
Journal	Pharmaceutical Research
Volume	16
Issue number	1
DOIs	https://doi.org/10.1023/A:1018828207920
State	Published - 1999
Externally published	Yes

ASJC Scopus Subject Areas

Biotechnology
Molecular Medicine
Pharmacology
Pharmaceutical Science
Organic Chemistry
Pharmacology (medical)

Keywords

Caco-2 cells
Chemical and enzymatic stability
Esterase-sensitive prodrugs
Membrane permeability
Opioid peptides
Peptide delivery

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10.1023/A:1018828207920

Cite this

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title = "Coumarinic acid-based cyclic prodrugs of opioid peptides that exhibit metabolic stability to peptidases and excellent cellular permeability",

keywords = "Caco-2 cells, Chemical and enzymatic stability, Esterase-sensitive prodrugs, Membrane permeability, Opioid peptides, Peptide delivery",

author = "Gudmundsson, \{Olafur S.\} and Pauletti, \{Giovanni M.\} and Wei Wang and Daxian Shan and Huijuan Zhang and Binghe Wang and Borchardt, \{Ronald T.\}",

year = "1999",

doi = "10.1023/A:1018828207920",

language = "English",

volume = "16",

pages = "7--15",

journal = "Pharmaceutical Research",

issn = "0724-8741",

number = "1",

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TY - JOUR

T1 - Coumarinic acid-based cyclic prodrugs of opioid peptides that exhibit metabolic stability to peptidases and excellent cellular permeability

AU - Gudmundsson, Olafur S.

AU - Pauletti, Giovanni M.

AU - Wang, Wei

AU - Shan, Daxian

AU - Zhang, Huijuan

AU - Wang, Binghe

AU - Borchardt, Ronald T.

PY - 1999

Y1 - 1999

KW - Caco-2 cells

KW - Chemical and enzymatic stability

KW - Esterase-sensitive prodrugs

KW - Membrane permeability

KW - Opioid peptides

KW - Peptide delivery

UR - https://www.scopus.com/pages/publications/0032937786

UR - https://www.scopus.com/pages/publications/0032937786#tab=citedBy

U2 - 10.1023/A:1018828207920

DO - 10.1023/A:1018828207920

M3 - Article

C2 - 9950272

AN - SCOPUS:0032937786

SN - 0724-8741

VL - 16

SP - 7

EP - 15

JO - Pharmaceutical Research

JF - Pharmaceutical Research

IS - 1

ER -

Coumarinic acid-based cyclic prodrugs of opioid peptides that exhibit metabolic stability to peptidases and excellent cellular permeability

ASJC Scopus Subject Areas

Keywords

Access to Document

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