Design and structural validation of peptide–drug conjugate ligands of the kappa-opioid receptor

Edin Muratspahić; Kristine Deibler; Jianming Han; Nataša Tomašević; Kirtikumar B. Jadhav; Aina Leonor Olivé-Marti; Nadine Hochrainer; Roland Hellinger; Johannes Koehbach; Jonathan F. Fay; Mohammad Homaidur Rahman; Lamees Hegazy; Timothy W. Craven; Balazs R. Varga; Gaurav Bhardwaj; Kevin Appourchaux; Susruta Majumdar; Markus Muttenthaler; Parisa Hosseinzadeh; David J. Craik; Mariana Spetea; Tao Che; David Baker; Christian W. Gruber

doi:10.1038/s41467-023-43718-w

Design and structural validation of peptide–drug conjugate ligands of the kappa-opioid receptor

Edin Muratspahić
, Kristine Deibler
, Jianming Han
, Nataša Tomašević
, Kirtikumar B. Jadhav
, Aina Leonor Olivé-Marti
, Nadine Hochrainer
, Roland Hellinger
, Johannes Koehbach
, Jonathan F. Fay
, Mohammad Homaidur Rahman
, Lamees Hegazy
, Timothy W. Craven
, Balazs R. Varga
, Gaurav Bhardwaj
, Kevin Appourchaux
, Susruta Majumdar
, Markus Muttenthaler
, Parisa Hosseinzadeh
, David J. Craik

Mariana Spetea, Tao Che, David Baker, Christian W. Gruber

Pharmaceutical and Administrative Sciences Department

Medical University of Vienna
University of Washington
Novo Nordisk A/S
Washington University School of Medicine in St. Louis
University of Vienna
University of Innsbruck
The University of Queensland
University of Maryland Baltimore
St. Louis College of Pharmacy
University of Oregon
University of Washington School of Medicine

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	8064
Journal	Nature Communications
Volume	14
Issue number	1
DOIs	https://doi.org/10.1038/s41467-023-43718-w
State	Published - Dec 2023

ASJC Scopus Subject Areas

General Chemistry
General Biochemistry,Genetics and Molecular Biology
General Physics and Astronomy

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10.1038/s41467-023-43718-w

Cite this

Muratspahić, E., Deibler, K., Han, J., Tomašević, N., Jadhav, K. B., Olivé-Marti, A. L., Hochrainer, N., Hellinger, R., Koehbach, J., Fay, J. F., Rahman, M. H., Hegazy, L., Craven, T. W., Varga, B. R., Bhardwaj, G., Appourchaux, K., Majumdar, S., Muttenthaler, M., Hosseinzadeh, P., ... Gruber, C. W. (2023). Design and structural validation of peptide–drug conjugate ligands of the kappa-opioid receptor. Nature Communications, 14(1), Article 8064. https://doi.org/10.1038/s41467-023-43718-w

Muratspahić, E, Deibler, K, Han, J, Tomašević, N, Jadhav, KB, Olivé-Marti, AL, Hochrainer, N, Hellinger, R, Koehbach, J, Fay, JF, Rahman, MH, Hegazy, L, Craven, TW, Varga, BR, Bhardwaj, G, Appourchaux, K, Majumdar, S, Muttenthaler, M, Hosseinzadeh, P, Craik, DJ, Spetea, M, Che, T, Baker, D & Gruber, CW 2023, 'Design and structural validation of peptide–drug conjugate ligands of the kappa-opioid receptor', Nature Communications, vol. 14, no. 1, 8064. https://doi.org/10.1038/s41467-023-43718-w

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title = "Design and structural validation of peptide–drug conjugate ligands of the kappa-opioid receptor",

author = "Edin Muratspahi{\'c} and Kristine Deibler and Jianming Han and Nata{\v s}a Toma{\v s}evi{\'c} and Jadhav, \{Kirtikumar B.\} and Oliv{\'e}-Marti, \{Aina Leonor\} and Nadine Hochrainer and Roland Hellinger and Johannes Koehbach and Fay, \{Jonathan F.\} and Rahman, \{Mohammad Homaidur\} and Lamees Hegazy and Craven, \{Timothy W.\} and Varga, \{Balazs R.\} and Gaurav Bhardwaj and Kevin Appourchaux and Susruta Majumdar and Markus Muttenthaler and Parisa Hosseinzadeh and Craik, \{David J.\} and Mariana Spetea and Tao Che and David Baker and Gruber, \{Christian W.\}",

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AU - Muratspahić, Edin

AU - Deibler, Kristine

AU - Han, Jianming

AU - Tomašević, Nataša

AU - Jadhav, Kirtikumar B.

AU - Olivé-Marti, Aina Leonor

AU - Hochrainer, Nadine

AU - Hellinger, Roland

AU - Koehbach, Johannes

AU - Fay, Jonathan F.

AU - Rahman, Mohammad Homaidur

AU - Hegazy, Lamees

AU - Craven, Timothy W.

AU - Varga, Balazs R.

AU - Bhardwaj, Gaurav

AU - Appourchaux, Kevin

AU - Majumdar, Susruta

AU - Muttenthaler, Markus

AU - Hosseinzadeh, Parisa

AU - Craik, David J.

AU - Spetea, Mariana

AU - Che, Tao

AU - Baker, David

AU - Gruber, Christian W.

PY - 2023/12

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VL - 14

JO - Nature Communications

JF - Nature Communications

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ER -

Design and structural validation of peptide–drug conjugate ligands of the kappa-opioid receptor

ASJC Scopus Subject Areas

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