Esterase-sensitive cyclic prodrugs of peptides: Evaluation of a phenylpropionic acid promoiety in a model hexapeptide

Giovanni M. Pauletti, Sanjeev Gangwar, Binghe Wang, Ronald T. Borchardt

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)11-17
Number of pages7
JournalPharmaceutical Research
Volume14
Issue number1
DOIs
StatePublished - 1997
Externally publishedYes

ASJC Scopus Subject Areas

  • Biotechnology
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry
  • Pharmacology (medical)

Keywords

  • Caco-2 cells
  • Chemical and enzymatic stability
  • Esterase-sensitive prodrug
  • Membrane permeability
  • Palmitoyl-DL-carnitine
  • Peptide delivery

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