Esterase-sensitive cyclic prodrugs of peptides: Evaluation of an acyloxyalkoxy promoiety in a model hexapeptide

Giovanni M. Pauletti; Sanjeev Gangwar; Franklin W. Okumu; Teruna J. Siahaan; Valentino J. Stella; Ronald T. Borchardt

doi:10.1023/A:1016472119387

Esterase-sensitive cyclic prodrugs of peptides: Evaluation of an acyloxyalkoxy promoiety in a model hexapeptide

Giovanni M. Pauletti, Sanjeev Gangwar, Franklin W. Okumu, Teruna J. Siahaan, Valentino J. Stella, Ronald T. Borchardt

The University of Kansas

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	1615-1623
Number of pages	9
Journal	Pharmaceutical Research
Volume	13
Issue number	11
DOIs	https://doi.org/10.1023/A:1016472119387
State	Published - 1996
Externally published	Yes

ASJC Scopus Subject Areas

Biotechnology
Molecular Medicine
Pharmacology
Pharmaceutical Science
Organic Chemistry
Pharmacology (medical)

Keywords

Caco-2 cells
Chemical stability
Enzymatic stability
Esterase-sensitive prodrug
Membrane permeability
Peptide delivery

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10.1023/A:1016472119387

Cite this

@article{7bd3890399344f7abd0029dfaf68894a,

title = "Esterase-sensitive cyclic prodrugs of peptides: Evaluation of an acyloxyalkoxy promoiety in a model hexapeptide",

keywords = "Caco-2 cells, Chemical stability, Enzymatic stability, Esterase-sensitive prodrug, Membrane permeability, Peptide delivery",

author = "Pauletti, {Giovanni M.} and Sanjeev Gangwar and Okumu, {Franklin W.} and Siahaan, {Teruna J.} and Stella, {Valentino J.} and Borchardt, {Ronald T.}",

year = "1996",

doi = "10.1023/A:1016472119387",

language = "English",

volume = "13",

pages = "1615--1623",

journal = "Pharmaceutical Research",

issn = "0724-8741",

number = "11",

}

TY - JOUR

T1 - Esterase-sensitive cyclic prodrugs of peptides

T2 - Evaluation of an acyloxyalkoxy promoiety in a model hexapeptide

AU - Pauletti, Giovanni M.

AU - Gangwar, Sanjeev

AU - Okumu, Franklin W.

AU - Siahaan, Teruna J.

AU - Stella, Valentino J.

AU - Borchardt, Ronald T.

PY - 1996

Y1 - 1996

KW - Caco-2 cells

KW - Chemical stability

KW - Enzymatic stability

KW - Esterase-sensitive prodrug

KW - Membrane permeability

KW - Peptide delivery

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U2 - 10.1023/A:1016472119387

DO - 10.1023/A:1016472119387

M3 - Article

C2 - 8956324

AN - SCOPUS:0030470532

SN - 0724-8741

VL - 13

SP - 1615

EP - 1623

JO - Pharmaceutical Research

JF - Pharmaceutical Research

IS - 11

ER -

Esterase-sensitive cyclic prodrugs of peptides: Evaluation of an acyloxyalkoxy promoiety in a model hexapeptide

ASJC Scopus Subject Areas

Keywords

Access to Document

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