Identification of Novel Mitochondrial Pyruvate Carrier Inhibitors by Homology Modeling and Pharmacophore-Based Virtual Screening

Lamees Hegazy, Lauren E. Gill, Kelly D. Pyles, Christopher Kaiho, Sophia Kchouk, Brian N. Finck, Kyle S. McCommis, Bahaa Elgendy

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Article number365
JournalBiomedicines
Volume10
Issue number2
DOIs
StatePublished - Feb 2022
Externally publishedYes

ASJC Scopus Subject Areas

  • Medicine (miscellaneous)
  • General Biochemistry,Genetics and Molecular Biology

Keywords

  • Homology modeling
  • Mitochondrial pyruvate carrier
  • Mutagenesis
  • Pharmacophore modeling
  • Virtual screening

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