Structure-based design and synthesis of conformationally constrained derivatives of methyl-piperidinopyrazole (MPP) with estrogen receptor (ER) antagonist activity

Mahmoud A. Ragab, Mohamed Elagawany, Hoda Daabees, Al Shaimaa F. Ahmed, Eman M. Awad, Cyrielle Billon, Bahaa Elgendy, Khaled A.M. Abouzid, Shaymaa E. Kassab

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Article number105554
JournalBioorganic Chemistry
Volume119
DOIs
StatePublished - Feb 2022
Externally publishedYes

ASJC Scopus Subject Areas

  • Biochemistry
  • Molecular Biology
  • Drug Discovery
  • Organic Chemistry

Keywords

  • Antiestrogens
  • Benzo-indazoles
  • Breast cancer
  • ER-full antagonist
  • Ligand binding domain
  • Tamoxifen

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