Structure-based design and synthesis of conformationally constrained derivatives of methyl-piperidinopyrazole (MPP) with estrogen receptor (ER) antagonist activity

Mahmoud A. Ragab; Mohamed Elagawany; Hoda Daabees; Al Shaimaa F. Ahmed; Eman M. Awad; Cyrielle Billon; Bahaa Elgendy; Khaled A.M. Abouzid; Shaymaa E. Kassab

doi:10.1016/j.bioorg.2021.105554

Structure-based design and synthesis of conformationally constrained derivatives of methyl-piperidinopyrazole (MPP) with estrogen receptor (ER) antagonist activity

Mahmoud A. Ragab, Mohamed Elagawany, Hoda Daabees, Al Shaimaa F. Ahmed, Eman M. Awad, Cyrielle Billon, Bahaa Elgendy, Khaled A.M. Abouzid, Shaymaa E. Kassab

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	105554
Journal	Bioorganic Chemistry
Volume	119
DOIs	https://doi.org/10.1016/j.bioorg.2021.105554
State	Published - Feb 2022
Externally published	Yes

ASJC Scopus Subject Areas

Biochemistry
Molecular Biology
Drug Discovery
Organic Chemistry

Keywords

Antiestrogens
Benzo-indazoles
Breast cancer
ER-full antagonist
Ligand binding domain
Tamoxifen

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10.1016/j.bioorg.2021.105554

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Ragab, M. A., Elagawany, M., Daabees, H., Ahmed, A. S. F., Awad, E. M., Billon, C., Elgendy, B., Abouzid, K. A. M., & Kassab, S. E. (2022). Structure-based design and synthesis of conformationally constrained derivatives of methyl-piperidinopyrazole (MPP) with estrogen receptor (ER) antagonist activity. Bioorganic Chemistry, 119, Article 105554. https://doi.org/10.1016/j.bioorg.2021.105554

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title = "Structure-based design and synthesis of conformationally constrained derivatives of methyl-piperidinopyrazole (MPP) with estrogen receptor (ER) antagonist activity",

keywords = "Antiestrogens, Benzo-indazoles, Breast cancer, ER-full antagonist, Ligand binding domain, Tamoxifen",

author = "Ragab, \{Mahmoud A.\} and Mohamed Elagawany and Hoda Daabees and Ahmed, \{Al Shaimaa F.\} and Awad, \{Eman M.\} and Cyrielle Billon and Bahaa Elgendy and Abouzid, \{Khaled A.M.\} and Kassab, \{Shaymaa E.\}",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",

year = "2022",

month = feb,

doi = "10.1016/j.bioorg.2021.105554",

language = "English",

volume = "119",

journal = "Bioorganic Chemistry",

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T1 - Structure-based design and synthesis of conformationally constrained derivatives of methyl-piperidinopyrazole (MPP) with estrogen receptor (ER) antagonist activity

AU - Ragab, Mahmoud A.

AU - Elagawany, Mohamed

AU - Daabees, Hoda

AU - Ahmed, Al Shaimaa F.

AU - Awad, Eman M.

AU - Billon, Cyrielle

AU - Elgendy, Bahaa

AU - Abouzid, Khaled A.M.

AU - Kassab, Shaymaa E.

PY - 2022/2

Y1 - 2022/2

KW - Antiestrogens

KW - Benzo-indazoles

KW - Breast cancer

KW - ER-full antagonist

KW - Ligand binding domain

KW - Tamoxifen

UR - https://www.scopus.com/pages/publications/85121212420

UR - https://www.scopus.com/inward/citedby.url?scp=85121212420&partnerID=8YFLogxK

U2 - 10.1016/j.bioorg.2021.105554

DO - 10.1016/j.bioorg.2021.105554

M3 - Article

C2 - 34923243

AN - SCOPUS:85121212420

SN - 0045-2068

VL - 119

JO - Bioorganic Chemistry

JF - Bioorganic Chemistry

M1 - 105554

ER -

Structure-based design and synthesis of conformationally constrained derivatives of methyl-piperidinopyrazole (MPP) with estrogen receptor (ER) antagonist activity

ASJC Scopus Subject Areas

Keywords

Access to Document

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