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Structure-based design and synthesis of conformationally constrained derivatives of methyl-piperidinopyrazole (MPP) with estrogen receptor (ER) antagonist activity

  • Mahmoud A. Ragab
  • , Mohamed Elagawany
  • , Hoda Daabees
  • , Al Shaimaa F. Ahmed
  • , Eman M. Awad
  • , Cyrielle Billon
  • , Bahaa Elgendy
  • , Khaled A.M. Abouzid
  • , Shaymaa E. Kassab

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Article number105554
JournalBioorganic Chemistry
Volume119
DOIs
StatePublished - Feb 2022
Externally publishedYes

ASJC Scopus Subject Areas

  • Biochemistry
  • Molecular Biology
  • Drug Discovery
  • Organic Chemistry

Keywords

  • Antiestrogens
  • Benzo-indazoles
  • Breast cancer
  • ER-full antagonist
  • Ligand binding domain
  • Tamoxifen

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