Transport characteristics of peptidomimetics. Effect of the pyrrolinone bioisostere on transport across Caco-2 cell monolayers

Masao Sudoh, Giovanni M. Pauletti, Wenqing Yao, William Moser, Akihisa Yokoyama, Alexander Pasternak, Paul A. Sprengeler, Amos B. Smith, Ralph Hirschmann, Ronald T. Borchardt

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)719-725
Number of pages7
JournalPharmaceutical Research
Volume15
Issue number5
DOIs
StatePublished - 1998
Externally publishedYes

ASJC Scopus Subject Areas

  • Biotechnology
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry
  • Pharmacology (medical)

Keywords

  • Caco-2 cells
  • Membrane permeability
  • Peptidomimetics
  • Polarized efflux systems
  • Pyrrolinone bioisostere

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