Transport characteristics of peptidomimetics. Effect of the pyrrolinone bioisostere on transport across Caco-2 cell monolayers

Masao Sudoh; Giovanni M. Pauletti; Wenqing Yao; William Moser; Akihisa Yokoyama; Alexander Pasternak; Paul A. Sprengeler; Amos B. Smith; Ralph Hirschmann; Ronald T. Borchardt

doi:10.1023/A:1011966918959

Transport characteristics of peptidomimetics. Effect of the pyrrolinone bioisostere on transport across Caco-2 cell monolayers

Masao Sudoh
, Giovanni M. Pauletti
, Wenqing Yao
, William Moser
, Akihisa Yokoyama
, Alexander Pasternak
, Paul A. Sprengeler
, Amos B. Smith
, Ralph Hirschmann
, Ronald T. Borchardt

University of Kansas School of Pharmacy
Texas Tech. Univ. Hlth. Sci. Center
University of Pennsylvania School of Arts and Sciences
Experimental Station, E500/3402B
DuPont
Nikko Kyodo Co., Ltd.
Merck & Co.
Arris Pharmaceutical Corporation

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	719-725
Number of pages	7
Journal	Pharmaceutical Research
Volume	15
Issue number	5
DOIs	https://doi.org/10.1023/A:1011966918959
State	Published - 1998
Externally published	Yes

ASJC Scopus Subject Areas

Biotechnology
Molecular Medicine
Pharmacology
Pharmaceutical Science
Organic Chemistry
Pharmacology (medical)

Keywords

Caco-2 cells
Membrane permeability
Peptidomimetics
Polarized efflux systems
Pyrrolinone bioisostere

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10.1023/A:1011966918959

Cite this

@article{18bde4881764435ea943fd3210e9c7c5,

title = "Transport characteristics of peptidomimetics. Effect of the pyrrolinone bioisostere on transport across Caco-2 cell monolayers",

keywords = "Caco-2 cells, Membrane permeability, Peptidomimetics, Polarized efflux systems, Pyrrolinone bioisostere",

author = "Masao Sudoh and Pauletti, \{Giovanni M.\} and Wenqing Yao and William Moser and Akihisa Yokoyama and Alexander Pasternak and Sprengeler, \{Paul A.\} and Smith, \{Amos B.\} and Ralph Hirschmann and Borchardt, \{Ronald T.\}",

year = "1998",

doi = "10.1023/A:1011966918959",

language = "English",

volume = "15",

pages = "719--725",

journal = "Pharmaceutical Research",

issn = "0724-8741",

number = "5",

}

TY - JOUR

T1 - Transport characteristics of peptidomimetics. Effect of the pyrrolinone bioisostere on transport across Caco-2 cell monolayers

AU - Sudoh, Masao

AU - Pauletti, Giovanni M.

AU - Yao, Wenqing

AU - Moser, William

AU - Yokoyama, Akihisa

AU - Pasternak, Alexander

AU - Sprengeler, Paul A.

AU - Smith, Amos B.

AU - Hirschmann, Ralph

AU - Borchardt, Ronald T.

PY - 1998

Y1 - 1998

KW - Caco-2 cells

KW - Membrane permeability

KW - Peptidomimetics

KW - Polarized efflux systems

KW - Pyrrolinone bioisostere

UR - https://www.scopus.com/pages/publications/15644375810

UR - https://www.scopus.com/pages/publications/15644375810#tab=citedBy

U2 - 10.1023/A:1011966918959

DO - 10.1023/A:1011966918959

M3 - Article

C2 - 9619780

AN - SCOPUS:15644375810

SN - 0724-8741

VL - 15

SP - 719

EP - 725

JO - Pharmaceutical Research

JF - Pharmaceutical Research

IS - 5

ER -

Transport characteristics of peptidomimetics. Effect of the pyrrolinone bioisostere on transport across Caco-2 cell monolayers

ASJC Scopus Subject Areas

Keywords

Access to Document

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