Tumor microenvironment-targeted nanoparticles loaded with bortezomib and ROCK inhibitor improve efficacy in multiple myeloma

Cinzia Federico; Kinan Alhallak; Jennifer Sun; Kathleen Duncan; Feda Azab; Gail P. Sudlow; Pilar de la Puente; Barbara Muz; Vaishali Kapoor; Luna Zhang; Fangzheng Yuan; Matea Markovic; Joseph Kotsybar; Katherine Wasden; Nicole Guenthner; Shannon Gurley; Justin King; Daniel Kohnen; Noha N. Salama; Dinesh Thotala; Dennis E. Hallahan; Ravi Vij; John F. DiPersio; Samuel Achilefu; Abdel Kareem Azab

doi:10.1038/s41467-020-19932-1

Tumor microenvironment-targeted nanoparticles loaded with bortezomib and ROCK inhibitor improve efficacy in multiple myeloma

Cinzia Federico
, Kinan Alhallak
, Jennifer Sun
, Kathleen Duncan
, Feda Azab
, Gail P. Sudlow
, Pilar de la Puente
, Barbara Muz
, Vaishali Kapoor
, Luna Zhang
, Fangzheng Yuan
, Matea Markovic
, Joseph Kotsybar
, Katherine Wasden
, Nicole Guenthner
, Shannon Gurley
, Justin King
, Daniel Kohnen
, Noha N. Salama
, Dinesh Thotala

Dennis E. Hallahan, Ravi Vij, John F. DiPersio, Samuel Achilefu, Abdel Kareem Azab

Pharmaceutical and Administrative Sciences Department

Washington University School of Medicine in St. Louis
Washington University in St. Louis
St. Louis College of Pharmacy
Cairo University

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	6037
Journal	Nature Communications
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41467-020-19932-1
State	Published - Dec 2020

ASJC Scopus Subject Areas

General Chemistry
General Biochemistry,Genetics and Molecular Biology
General Physics and Astronomy

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10.1038/s41467-020-19932-1

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Federico, C., Alhallak, K., Sun, J., Duncan, K., Azab, F., Sudlow, G. P., de la Puente, P., Muz, B., Kapoor, V., Zhang, L., Yuan, F., Markovic, M., Kotsybar, J., Wasden, K., Guenthner, N., Gurley, S., King, J., Kohnen, D., Salama, N. N., ... Azab, A. K. (2020). Tumor microenvironment-targeted nanoparticles loaded with bortezomib and ROCK inhibitor improve efficacy in multiple myeloma. Nature Communications, 11(1), Article 6037. https://doi.org/10.1038/s41467-020-19932-1

Federico, C, Alhallak, K, Sun, J, Duncan, K, Azab, F, Sudlow, GP, de la Puente, P, Muz, B, Kapoor, V, Zhang, L, Yuan, F, Markovic, M, Kotsybar, J, Wasden, K, Guenthner, N, Gurley, S, King, J, Kohnen, D, Salama, NN, Thotala, D, Hallahan, DE, Vij, R, DiPersio, JF, Achilefu, S & Azab, AK 2020, 'Tumor microenvironment-targeted nanoparticles loaded with bortezomib and ROCK inhibitor improve efficacy in multiple myeloma', Nature Communications, vol. 11, no. 1, 6037. https://doi.org/10.1038/s41467-020-19932-1

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title = "Tumor microenvironment-targeted nanoparticles loaded with bortezomib and ROCK inhibitor improve efficacy in multiple myeloma",

author = "Cinzia Federico and Kinan Alhallak and Jennifer Sun and Kathleen Duncan and Feda Azab and Sudlow, \{Gail P.\} and \{de la Puente\}, Pilar and Barbara Muz and Vaishali Kapoor and Luna Zhang and Fangzheng Yuan and Matea Markovic and Joseph Kotsybar and Katherine Wasden and Nicole Guenthner and Shannon Gurley and Justin King and Daniel Kohnen and Salama, \{Noha N.\} and Dinesh Thotala and Hallahan, \{Dennis E.\} and Ravi Vij and DiPersio, \{John F.\} and Samuel Achilefu and Azab, \{Abdel Kareem\}",

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doi = "10.1038/s41467-020-19932-1",

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T1 - Tumor microenvironment-targeted nanoparticles loaded with bortezomib and ROCK inhibitor improve efficacy in multiple myeloma

AU - Federico, Cinzia

AU - Alhallak, Kinan

AU - Sun, Jennifer

AU - Duncan, Kathleen

AU - Azab, Feda

AU - Sudlow, Gail P.

AU - de la Puente, Pilar

AU - Muz, Barbara

AU - Kapoor, Vaishali

AU - Zhang, Luna

AU - Yuan, Fangzheng

AU - Markovic, Matea

AU - Kotsybar, Joseph

AU - Wasden, Katherine

AU - Guenthner, Nicole

AU - Gurley, Shannon

AU - King, Justin

AU - Kohnen, Daniel

AU - Salama, Noha N.

AU - Thotala, Dinesh

AU - Hallahan, Dennis E.

AU - Vij, Ravi

AU - DiPersio, John F.

AU - Achilefu, Samuel

AU - Azab, Abdel Kareem

PY - 2020/12

Y1 - 2020/12

UR - https://www.scopus.com/pages/publications/85096740244

UR - https://www.scopus.com/pages/publications/85096740244#tab=citedBy

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DO - 10.1038/s41467-020-19932-1

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AN - SCOPUS:85096740244

SN - 2041-1723

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JO - Nature Communications

JF - Nature Communications

IS - 1

M1 - 6037

ER -

Tumor microenvironment-targeted nanoparticles loaded with bortezomib and ROCK inhibitor improve efficacy in multiple myeloma

ASJC Scopus Subject Areas

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